Subject: Nature Contents: 10 March 2005 Volume 434 No. 7030 pp123-256

From: "NatureAlert"<[email-masked]>
Date: Wed, 09 Mar 2005 13:47:22 -0500 (EST)

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10 March 2005

Editorials
News
News Feature
Correspondence
Books and Arts
The Physics Detective
Concepts
News and Views
Brief Communications
Articles
Letters to Nature
Naturejobs
Futures

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Feature of the week

Murder by medicine
Across the developing world, people are dying after being peddled fake pharmaceuticals. In this special News Feature Peter Aldhous reports from southeast Asia, where scientists, doctors and regulators battle against organized crime.

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| Editorials |

Killers on the loose 123
Across the developing world, seriously ill patients can't be sure whether they're purchasing life-saving medicines or worthless dummy pills. This scandal demands a stronger response from aid donors, governments and the drugs industry.
doi:10.1038/434123a
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Bad faith at Los Alamos 123
The breakdown of an old contract threatens to leave a great national laboratory gravely weakened.
doi:10.1038/434123b
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| News |

NASA's funding shortfall means journey's end for Voyager probes 125
Mission to the edge of the Solar System may shut down in October to save cash.
doi:10.1038/434125a
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Senate resignations mar academy's birthday 126
European Academy of Sciences and Arts faces unrest.
doi:10.1038/434126a
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Anthropologists walk tall after unearthing hominid 126
Ethiopian fossil should shed light on mankind's first upright steps.
doi:10.1038/434126b
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Career charter sets out rights of Europe's young scientists 127
PhD students get leverage to be treated properly as professionals.
doi:10.1038/434127a
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Gene-therapy trials to restart following cancer risk review 127
US researchers to trial gene therapy on children with SCID.
doi:10.1038/434127b
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Climatologists seek clear view of Asia's smog 128
Project to assess climate impact of massive brown clouds.
doi:10.1038/434128a
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Biosafety law brings stem-cell research to Brazil 128
Extra embryos from IVF now open for research - but not for therapeutic cloning.
doi:10.1038/434128b
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Police urge speedy action to clean up home drug factories 129
Illegal methamphetamine labs could turn houses to toxic dumps.
doi:10.1038/434129a
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Science agencies get fresh paymasters in Republican revamp 129
NSF and NASA get new funding bosses in US Congress.
doi:10.1038/434129b
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news in brief 130
doi:10.1038/434130a
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| News Feature |

Counterfeit pharmaceuticals: Murder by medicine 132
Across the developing world, people are dying after being peddled fake pharmaceuticals. Peter Aldhous reports from southeast Asia, where scientists, doctors and regulators battle against organized crime.
doi:10.1038/434132a
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Counterfeit pharmaceuticals: In the line of fire 134
Dora Akunyili has spent the past four years facing down corruption and tackling Nigeria's rampant problems with fake drugs. This crusade has been phenomenally successful, but has placed Akunyili's life in danger. Peter Aldhous caught up with her on a recent trip to the United States.
doi:10.1038/434134a
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| Correspondence |

HIV drug remains unproven without placebo trial 137
Ethical concerns over use of a placebo weaken evidence for the benefits of nevirapine.
doi:10.1038/434137a
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Concern over deep-sea reefs is widespread 137
doi:10.1038/434137b
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Brown knew particles were smaller than pollen 137
doi:10.1038/434137c
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| Books and Arts |

A part of but apart from politics 139
ROGER PIELKE JR reviews Nature's Experts: Science, Politics, and the Environment by Stephen Bocking
Can scientists advise policy-makers without compromising their objectivity?
doi:10.1038/434139a
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Marketing Marie 140
SUSAN LINDEE reviews Obsessive Genius: The Inner World of Marie Curie by Barbara Goldsmith
doi:10.1038/434140a
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Science in culture 141
MARTIN KEMP
The artist Joseph Beuys tried to lead his followers into a promised land of transformative imagination.
doi:10.1038/434141a
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Rivalry and revenge 142
NICOLA NOSENGO reviews Costantinopoli 1786: la congiura e la beffa (Constantinople 1786: The Conspiracy and the Hoax) by Paolo Mazzarello
doi:10.1038/434142a
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| The Physics Detective |

Schrödinger's mousetrap 143
JACK COHEN
Part 8: The outcast.
doi:10.1038/434143a
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| Concepts |

Eggs alone 145
ANN A. KIESSLING
Human parthenotes: an ethical source of stem cells for therapies?
doi:10.1038/434145a
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| News and Views |

Biodiversity: Fossils make waves 147
JAMES W. KIRCHNER AND ANNE WEIL
A 62-million-year cycle in biodiversity emerges from scrutiny of a marine-fossil database, but its causes remain mysterious. Thus, this discovery is likely to provoke a flurry of theoretical speculation.
doi:10.1038/434147a
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Astronomy: Stellar mass limited 148
PAVEL KROUPA
Is there an upper limit to the mass of a star? The answer to this long-standing question seems to be yes — and it has important consequences for our understanding of the evolution of galaxies.
doi:10.1038/434148a
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100 and 50 years ago 149
doi:10.1038/434149a
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Epigenetics: Surveillance team against cancer 150
GEORGE KLEIN
Variations in the control of a phenomenon known as parental imprinting influence the likelihood of tumour development. These new findings may tie in with an earlier concept of 'two-phase' carcinogenesis.
doi:10.1038/434150a
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Semiconductor technology: Negatively successful 151
ANANTH DODABALAPUR
Organic semiconducting polymers are promising electronic materials, but for full versatility they need to conduct negative as well as positive charge. A step towards that goal has now been taken.
doi:10.1038/434151a
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Structural biology: Methanol maker 151
JOSHUA FINKELSTEIN
doi:10.1038/434151b
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Developmental biology: Sperm–egg fusion unscrambled 152
RICHARD SCHULTZ AND CARMEN WILLIAMS
The identity of the sperm molecules that are involved in fusion with an egg's membrane has eluded biologists. Will Izumo, a protein named after the Japanese shrine to marriage, bring harmony to the field?
doi:10.1038/434152a
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Planetary sciences: A smashing pair 153
JAY MELOSH
The likely origin of Pluto and its satellite Charon, like the Earth and Moon, is an impact between two planet-sized bodies. Refined simulations show that there may be two distinct modes for the birth of such twins.
doi:10.1038/434153a
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Animal behaviour: Meals sized up 154
RORY HOWLETT
doi:10.1038/434154a
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Palaeobiology: Dating earliest life 155
STEPHEN MOORBATH
Claims that 3.8-billion-year-old rocks from Greenland contain carbonaceous remnants of very early life have been the subject of argument for several years. The latest analyses look like settling matters.
doi:10.1038/434155a
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Research highlights 156
doi:10.1038/434156a
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| Brief Communications |

Planetary science: Meteor Crater formed by low-velocity impact 157
H. J. MELOSH AND G. S. COLLINS
The paucity of melted rock in this crater may be due to the striking projectile's speed.
doi:10.1038/434157a
First paragraph | Full Text

Musical imagery: Sound of silence activates auditory cortex 158
DAVID J. M. KRAEMER, C. NEIL MACRAE, ADAM E. GREEN & WILLIAM M. KELLEY
doi:10.1038/434158a
First paragraph | Full Text

| Articles |

Imaging of Titan from the Cassini spacecraft 159
CAROLYN C. PORCO, et al.
doi:10.1038/nature03436
Summary | Full Text

Experimental one-way quantum computing 169
P. WALTHER, et al.
doi:10.1038/nature03347
Summary | Full Text

Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane 177
RAQUEL L. LIEBERMAN AND AMY C. ROSENZWEIG
doi:10.1038/nature03311
Summary | Full Text

Structural basis of HutP-mediated anti-termination and roles of the Mg2+ ion and L-histidine ligand 183
THIRUMANANSERI KUMAREVEL, HIROSHI MIZUNO & PENMETCHA K. R. KUMAR
doi:10.1038/nature03355
Summary | Full Text

| Letters to Nature |

An upper limit to the masses of stars 192
DONALD F. FIGER
doi:10.1038/nature03293
First paragraph | Full Text

General observation of n-type field-effect behaviour in organic semiconductors 194
LAY-LAY CHUA, et al.
doi:10.1038/nature03376
First paragraph | Full Text

Ultrafast memory loss and energy redistribution in the hydrogen bond network of liquid H2O 199
M. L. COWAN, et al.
doi:10.1038/nature03383
First paragraph | Full Text

The formation of cubic ice under conditions relevant to Earth's atmosphere 202
BENJAMIN J. MURRAY, DANIEL A. KNOPF & ALLAN K. BERTRAM
doi:10.1038/nature03403
First paragraph | Full Text

Measuring the onset of locking in the Peru–Chile trench with GPS and acoustic measurements 205
KATIE GAGNON, C. DAVID CHADWELL & EDMUNDO NORABUENA
doi:10.1038/nature03412
First paragraph | Full Text

Cycles in fossil diversity 208
ROBERT A. ROHDE AND RICHARD A. MULLER
doi:10.1038/nature03339
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Agricultural runoff fuels large phytoplankton blooms in vulnerable areas of the ocean 211
J. MICHAEL BEMAN, KEVIN R. ARRIGO & PAMELA A. MATSON
doi:10.1038/nature03370
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The global distribution of clinical episodes of Plasmodium falciparum malaria 214
ROBERT W. SNOW, et al.
doi:10.1038/nature03342
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Mediation of pathogen resistance by exudation of antimicrobials from roots 217
HARSH P. BAIS, BALAKRISHNAN PRITHIVIRAJ, AJAY K. JHA, FREDERICK M. AUSUBEL & JORGE M. VIVANCO
doi:10.1038/nature03356
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Spike-timing-dependent synaptic plasticity depends on dendritic location 221
ROBERT C. FROEMKE, MU-MING POO & YANG DAN
doi:10.1038/nature03366
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The receptors and coding logic for bitter taste 225
KEN L. MUELLER, et al.
doi:10.1038/nature03352
First paragraph | Full Text

Spatial bistability of Dpp–receptor interactions during Drosophila dorsal–ventral patterning 229
YU-CHIUN WANG AND EDWIN L. FERGUSON
doi:10.1038/nature03318
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The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs 234
NAOKAZU INOUE, MASAHITO IKAWA, AYAKO ISOTANI & MASARU OKABE
doi:10.1038/nature03362
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Agonist/endogenous peptide–MHC heterodimers drive T cell activation and sensitivity 238
MICHELLE KROGSGAARD, et al.
doi:10.1038/nature03391
First paragraph | Full Text

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors 243
AKINORI TAKAOKA, et al.
doi:10.1038/nature03308
First paragraph | Full Text

| Naturejobs |

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| | Post-Doc | | | | NestlÃ© | | Lausanne, Switzerland |
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| Biochemist | | | | GE-Global Research Center | | Niskayuna, NY United States
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| Research Fellow | | Bioinformatics|Computer Science|Biochemistry|Drug Discovery|Structural Biology| | | Fujirebio, Inc. | | Tokyo, Japan
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| Software Engineer | | Computer Science|Diagnostics|Engineering|Molecular Biology|Gene Therapy|Bioinformatics|Cancer Research / Oncology| | | European Molecular Biology Laboratory | | Heidelberg, Germany D-69012
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| Laboratory Assistant | | Computer Science|Diagnostics|Engineering|Molecular Biology|Gene Therapy|Bioinformatics|Cancer Research / Oncology| | | European Molecular Biology Laboratory | | Heidelberg, Germany D-69012
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| Postdoctoral Fellow / Research Fellow | | Bioinformatics|Biological Sciences|Molecular Biology | | Research School of Biological Sciences / Genomics Interaction Group / Arc Centre of Excellence for Integrative Legume Research | | Canberra, Australia
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More Naturejobs

In the picture 251
PAUL SMAGLIK
doi:10.1038/nj7030-251a
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Come together 252
PAUL SMAGLIK
The addition of molecular biology to the existing range of imaging technologies is creating opportunities for scientists of many disciplines. Paul Smaglik lines up the pieces.
doi:10.1038/nj7030-252a
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| Futures |

A man of the theatre 256
NORMAN SPINRAD
All the world's a stage.
doi:10.1038/434256a
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