Subject: [BABDG] Reminder--March 24: Irene Gabashvili, Hewlett-Packard Labs

From: "[BABDG]" <[email-masked]>
Date: Wed, 23 Mar 2005 18:43:28 -0600

A quick reminder about our March 24 meeting coming up...

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New Genes Worth Hearing About

Irene Gabashvili
Senior Scientist
Department of Advanced Studies
Hewlett-Packard Labs

Thursday, March 24, 2005
7:00 to 8:00 p.m. Presentation
8:00 to 9:00 p.m. Discussion and Announcements

Munzer Auditorium
Stanford University

(Unless otherwise noted, all BAB events are free of charge and require no RSVP or registration.)

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Abstract:

Reading this abstract might seem effortless, yet it involves billions of circuits flashing messages along pathways and feedback loops in our brain. Listening is not any simpler, for it relies on thousands of proteins, genes and essential nutrients. The extreme complexity of our hearing apparatus is demonstrated by hundreds of genes causing deafness. Hundreds more are still awaiting their discovery. Over fifteen thousand ESTs from human cochlea and over nineteen thousand sequences from the mouse organ of Corti were provided to our computational biosciences group at HP Labs by Hearing Research Groups at Harvard and NIH. Using software developed in our group, we have mapped these sequences to the latest available versions of human and mouse genomes and known protein families. The program helped to filter out genomic and external contaminations and identify genetic rearrangements. A large amount of not yet annotated genetic isoforms was found and will be described in detail on a 
specific example of ion channel genes. We have identified candidates of primary sound and pitch perception complexes and mapped pathways related to cell growth and maintenance. This talk will also focus on tissue-specificity and gene sharing between different organs.

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Speaker Background:

Dr. Irene Gabashvili is a Senior Scientist in the Department of Advanced Studies at Hewlett-Packard Labs. Her research interest is analysis and interpretation of large datasets. Her current work focuses on the genetics of hearing. Irene did her graduate study with Alexander Grosberg and George Mrevlishvili on statistical physical aspects of viral infection. In the pre-human genome days, she had worked in the area of genetic epidemiology. Prior to joining Hewlett-Packard, she held postdoctoral and research scientist positions at the Center for Photobiophysics, University of Quebec; Department of Biochemistry, University of Texas Health Science Center; Laboratory of Computational Biology and Molecular Imaging at Wadsworth Center NYS Department of Health (with Joachim Frank), and Stanford University (with Russ Altman). More information available at: http://www.hpl.hp.com/personal/Irene_Gabashvili/.

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Directions to Munzer Auditorium at Stanford University:

http://cmgm.stanford.edu/munzer/location.html

Munzer Auditorium is in the Beckman Center. A map of this area of the Stanford campus is here:

http://www.med.stanford.edu/maps/sumc.html

Parking in the lot near the Beckman Center is unrestricted after 5 p.m. 

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