Subject: Nature 12 April 2007 Volume 446 Number 7137, pp701-830

From: "Nature Alert"<[email-masked]>
Date: Wed, 11 Apr 2007 14:31:57 -0400 (EDT)

TABLE OF CONTENTS

Volume 446 Number 7137 pp701-830

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In this issue
Editorials
Research Highlights
News
Column
Business
News Features
Correspondence
Commentary
Books and Arts
Essay
News and Views
News and Views Q&A
Review
Articles
Letters
Corrigendum
Addendum

Also this week
Authors
Editor's summary
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Editorials

Top

Climate change, here and now p701
Poor nations need the data that show what is already happening to their climate, as well as the resources with which to adapt to change.
10.1038/446701a
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Science without borders p701
Researchers should push for rule changes to make Europe work as one.
10.1038/446701b
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When employees attack p702
Government scientists should be able to comment publicly — within reason.
10.1038/446702a
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Research Highlights

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Research highlights p704
10.1038/446704a
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News

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Climate takes aim p706
Attention is now turning to the developing world, where those least equipped to handle it will bear the brunt of global warming.
Michael Hopkin reports.
10.1038/446706a
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Dinosaur prints lead to crediting row p708
Turf war overshadows discovery of sauropod tracks.
Rex Dalton
10.1038/446708a
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Physicists question model of the Universe p709
The search continues for a non-standard theory.
Jenny Hogan
10.1038/446709a
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Venezuelan free-speech row goes nuclear p711
Physicist is demoted after criticizing government officials.
Michael Hopkin
10.1038/446711a
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Column

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Party of One
Back to school p714
The US National Science Foundation may soon have to supply lab equipment to poverty-stricken high schools. David Goldston explains why some politicians want the agency to pay for Bunsen burners and test-tubes.
David Goldston
10.1038/446714a
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Business

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Plastic promises p715
Car companies know that plastic parts made from plants will appeal to 'green' customers. But as Ichiko Fuyuno reports, their progress has been painfully slow.
10.1038/446715a
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News Features

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Climate Change 2007: How to survive a warming world p716
African communities have been adapting to climate change for millennia. Jim Giles reports on the strategies that seem most effective.
10.1038/446716a
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Climate Change 2007: A world melting from the top down p718
Despite years of speculation, little can be said for sure about the future of the Arctic's permafrost. But that's no grounds for complacency, reports Gabrielle Walker.
10.1038/446718a
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Climate Change 2007: Al's Army p723
Members of the public are taking to the streets to spread Al Gore's message of climate crisis. Amanda Haag meets the foot soldiers of global warming.
10.1038/446723a
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Correspondence

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Save your notes, drafts and printouts: today's work is tomorrow's history p725
Sydney Brenner and Richard J. Roberts
10.1038/446725a
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See also: Editor's summary

Reliance on bibliometric databases can let you down p725
Brian Haynes
10.1038/446725b
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Increasing prose quality by decreasing word repetition p725
Cheryl Strauss
10.1038/446725c
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Commentary

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Climate change 2007: Spring-time for sinks p727
Carbon sinks play a key role in slowing the growth of carbon dioxide levels in the atmosphere. These sinks are at risk as the world warms, but their demise is not inevitable, say Dave Reay and his colleagues.
10.1038/446727a
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See also: Editor's summary

Books and Arts

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Industrial relations p729
What lessons can be learned from a landmark deal between a company and a university department?
Scott Wallsten reviews Universities in the Age of Corporate Science: The UC Berkeley-Novartis Controversy by Alan P. Rudy Dawn Coppin Jason Konefal Bradley T. Shaw Toby Ten Eyck Craig Harris Lawrence Busch
10.1038/446729a
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Builders with little brains p730
Tore Slagsvold reviews Animal Architects: Building and the Evolution of Intelligence by James L. Gould Carol Grant Gould
10.1038/446730a
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The birth of science p731
Peter Dear reviews The Emergence of a Scientific Culture: Science and the Shaping of Modernity 1210–1685 by Stephen Gaukroger
10.1038/446731a
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Science books award p731
10.1038/446731b
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Essay

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Capturing human behaviour p733
Understanding the dynamics of infectious-disease transmission demands a holistic approach, yet today's models largely ignore how epidemics change individual behaviour.
Neil Ferguson
10.1038/446733a
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See also: Editor's summary

News and Views

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Cancer: Division of labour p735
Some genes are involved in the development of a new tumour; others specifically promote the dissemination of its cancerous cells to other organs. A set of four genes seems to be required for both processes.
Gerhard Christofori
10.1038/446735a
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See also: Editor's summary

Solid-state chemistry: Crystal tennis rackets p736
The idea of bendy crystals, especially ones that move rapidly and reversibly in response to light, seems strange. Such materials have now been prepared — but how do they change shape so dramatically without cracking?
J. Michael McBride
10.1038/446736a
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See also: Editor's summary

50 & 100 Years Ago p737
10.1038/446737a
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Genomics: Global views of leukaemia p739
Genomic characterization of a type of leukaemia has resulted in the identification of common genetic abnormalities that underlie the disease. The results constitute an advance on several fronts.
Todd R. Golub
10.1038/446739a
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See also: Editor's summary

Geology: Crystal-clear ideas p739
Richard Webb
10.1038/446739b
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Biophysics: Quantum path to photosynthesis p740
Knowing how plants and bacteria harvest light for photosynthesis so efficiently could provide a clean solution to mankind's energy requirements. The secret, it seems, may be the coherent application of quantum principles.
Roseanne J. Sension
10.1038/446740a
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See also: Editor's summary

Cell biology: Fraternal twins p741
A popular route for protein transport into and across cell membranes is through the Sec channel. This channel seems to function by forming a dimer of two identical units, where each has a distinct role.
Franck Duong
10.1038/446741a
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Ecology: Poole resources p743
Tim Lincoln
10.1038/446743a
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Obituary: Knut Schmidt-Nielsen (1915–2007) p744
Quests in comparative physiology.
R. McNeill Alexander
10.1038/446744a
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News and Views Q&A

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Cell biology: Autophagy and cancer p745
Autophagy is the degradation of redundant or faulty cell components. It occurs as part of a cell's everyday activities and as a response to stressful stimuli, such as starvation. Connections with cellular life-and-death decisions and with cancer are now emerging.
Beth Levine
10.1038/446745a
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Review

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Multiple molecular mechanisms for multidrug resistance transporters p749
Christopher F. Higgins
10.1038/nature05630
First paragraph | Full Text | PDF
See also: Editor's summary

Articles

Top

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia p758
A genome-wide, high-resolution single nucleotide polymorphism array analysis of a large number of acute lymphoblastic leukaemia samples identifies a number of genomic changes. These include alterations in the genes encoding Pax5 and other regulators of B-cell development and differentiation.
Charles G. Mullighan et al.
10.1038/nature05690
Abstract | Full Text | PDF
See also: Editor's summary | News and Views by Golub

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis p765
Previous studies identified genes involved in tissue-specific metastasis of breast cancer cells to the lung. New work now shows how four of these genes cooperate to remodel the vasculature and thereby both tumour cell intravasation into the circulation and extravasation of blood vessels in the lung to form metastases.
Gaorav P. Gupta et al.
10.1038/nature05760
Abstract | Full Text | PDF
See also: Editor's summary | News and Views by Christofori

Letters

Top

A laboratory demonstration of the capability to image an Earth-like extrasolar planet p771
An Earth-like planet orbiting a nearby star is 1 × 10−10 times fainter than the star at angular separations of typically 0.1 arcsecond or less, but this paper reports an experiment that suppresses the diffracted and scattered light near a star-like source to a level of 6 × 10−10 in individual coronagraph images.
John T. Trauger and Wesley A. Traub
10.1038/nature05729
First paragraph | Full Text | PDF
See also: Editor's summary

Optical coherent state discrimination using a closed-loop quantum measurement p774
The laboratory implementation of quantum measurement procedures is difficult, relying on delicate quantum superpositions known as Schroedinger cat states. Here, an alternative technique is demonstrated to perform an optimal quantum measurement, using real-time quantum feedback. The measurement achieves its fundamental quantum limit over a non-trivial region of parameter space.
Robert L. Cook, Paul J. Martin and J. M. Geremia
10.1038/nature05655
First paragraph | Full Text | PDF
See also: Editor's summary

Rapid and reversible shape changes of molecular crystals on photoirradiation p778
A new material of molecular crystals, based on diarylethene chromophores and with sizes ranging from 10 to 100 micrometers, can be switched rapidly and reversibly between two different stable states by irradiation with ultraviolet and visible light, respectively. When put in the spotlight, a rod-shaped crystal of the material attached to a surface will even oblige and 'bat' away a micrometer-sized gold particle.
Seiya Kobatake et al.
10.1038/nature05669
First paragraph | Full Text | PDF
See also: Editor's summary | News and Views by McBride

Evidence for wavelike energy transfer through quantum coherence in photosynthetic systems p782
A spectroscopic study has directly monitored the quantum beating arising from remarkably long-lived electronic quantum coherence in a bacteriochlorophyll complex. This wavelike characteristic of the energy transfer process can explain the extreme efficiency of photosynthesis, in that vast areas of phase space can be sampled effectively to find the most efficient path for energy transfer.
Gregory S. Engel et al.
10.1038/nature05678
First paragraph | Full Text | PDF
See also: Editor's summary | News and Views by Sension

A periodic shear-heating mechanism for intermediate-depth earthquakes in the mantle p787
Peter B. Kelemen and Greg Hirth
10.1038/nature05717
First paragraph | Full Text | PDF

Grassland species loss resulting from reduced niche dimension p791
Although resource limitation is not the only factor that could explain species richness and biodiversity, it is shown that it explains bidoversity in experimental grass plots in California, and could explain results in the long-running Park Grass Experiment in the UK.
W. Stanley Harpole and David Tilman
10.1038/nature05684
First paragraph | Full Text | PDF
See also: Editor's summary

Egalitarian motives in humans p794
Christopher T. Dawes et al.
10.1038/nature05651
First paragraph | Full Text | PDF
See also: Editor's summary

A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis p797
In the developing neural tube of the zebrafish, a newly discovered kind of cell division occurs that produces two daughter cells with mirror symmetry. Cells are polarized in mirror symmetry on either side of the neural midline, and Pard3, a protein known to be involved in polarized cell divisions, is deposited within the cleavage furrow of the midline.
Marcel Tawk et al.
10.1038/nature05722
First paragraph | Full Text | PDF

Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry p801
Matthew J. Evans et al.
10.1038/nature05654
First paragraph | Full Text | PDF
See also: Editor's summary

Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map p806
An epistatic miniarray profile allows identification of multiprotein complexes involved in various aspects of chromosome biology. In one pathway, the histone acetyltransferase Rtt109 is found to modify histone H3 lysine 56 during DNA replication.
Sean R. Collins et al.
10.1038/nature05649
First paragraph | Full Text | PDF

Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers p811
Throughout the lifespan of a plant, the stem cell niches in the shoot and root apical meristems provide the cells for the formation of new tissues and organs. Here, evidence is presented that the signalling centres of both niches utilize related transcription factors, WUSCHEL and WOX5, respectively, to maintain neighbouring stem cells undifferentiated.
Ananda K. Sarkar et al.
10.1038/nature05703
First paragraph | Full Text | PDF
See also: Editor's summary

Synthetic lethal screen identification of chemosensitizer loci in cancer cells p815
Angelique W. Whitehurst et al.
10.1038/nature05697
First paragraph | Full Text | PDF

Backtracking determines the force sensitivity of RNAP II in a factor-dependent manner p820
Eric A. Galburt et al.
10.1038/nature05701
First paragraph | Full Text | PDF

Corrigendum

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The Polycomb group protein EZH2 directly controls DNA methylation p824
Emmanuelle Viré et al.
10.1038/nature05710
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Addendum

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Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor p824
Marcos H. Hatada et al.
10.1038/nature05727
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Naturejobs

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Prospect
Young scientists flock to networking sites. p825
Paul Smaglik
10.1038/nj7137-825a
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Careers and Recruitment
Genes versus cancer p826
Just a decade has changed cancer research beyond recognition, but adaptable skills and teamwork lead to exciting possibilities.
Ricki Lewis looks at the new face of cancer genetics.
10.1038/nj7137-826a
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Stephen Cohen, director, Temasek Life Sciences Laboratory, Singapore p828
Canadian researcher switches continents yet again.
Ichiko Fuyuno
10.1038/nj7137-828a
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Crossing boundaries p828
Fellow finds interdicisplinary options.
Giovanni Frazzetto
10.1038/nj7137-828b
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Missing the mundane p828
Postdoc adapting to new minutae in South Africa.
Chris Rowan
10.1038/nj7137-828c
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Recruiters
The inside track from academia and industry: Tough sell p830
Let's talk money: what you're likely to earn, how to get a pay rise and when to consider other options.
Martin Lang
10.1038/nj7137-830a
Full Text | PDF

Advance Online Publication

Top

11 April 2007
LETTERS
A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein
K. Hun Mok et al.
doi:10.1038/nature05728
First Paragraph | Full Text | PDF | Supplementary information

RNA-templated DNA repair
Francesca Storici, Katarzyna Bebenek, Thomas A. Kunkel, Dmitry A. Gordenin & Michael A. Resnick
doi:10.1038/nature05720
First Paragraph | Full Text | PDF | Supplementary information

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
Travis H. Stracker, Monica Morales, Suzana S. Couto, Hussein Hussein & John H. J. Petrini
doi:10.1038/nature05740
First Paragraph | Full Text | PDF | Supplementary information

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