Subject: Nature Biotechnology Contents: May 2007 Volume 25 pp. 483 - 602

From: "Nature Biotechnology Alert"<[email-masked]>
Date: Wed, 09 May 2007 10:45:21 -0400 (EDT)

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TABLE OF CONTENTS

May 2007 Volume 25, Issue 5

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In This Issue
Editorial
News
Bioentrepreneur
Opinion and Comment
Features
News and Views
Computational Biology
Research
Naturejobs

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In This Issue

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Editorial

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Probity gone nuts p483
The thinking behind the US Food and Drug Administration's (FDA) draft guidance on financial conflicts of interest for outside experts is deeply flawed.
10.1038/nbt0507-483
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News

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Critics pan timid European response to TeGenero disaster pp485 - 486
Peter Mitchell
10.1038/nbt0507-485
Abstract | Full Text | PDF

Cimzia's setback paves way for other TNF inhibitors in Crohn's disease pp487 - 488
Cormac Sheridan
10.1038/nbt0507-487
Abstract | Full Text | PDF

Despite glacial progress, US government signals support for personalized medicine pp489 - 490
Jeffrey L. Fox
10.1038/nbt0507-489
Abstract | Full Text | PDF

Will the current biofuels boom go bust? pp491 - 492
Emily Waltz
10.1038/nbt0507-491
Abstract | Full Text | PDF

In Brief

News in brief pp493 - 494
10.1038/nbt0507-493
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Profile

Profile: Susan Wood p495
Ken Wilan
10.1038/nbt0507-495
Abstract | Full Text | PDF

Data Page

VC funding hits high in Q1 p496
Stacy Lawrence
10.1038/nbt0507-496
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News Feature

Antisense[mdash]down, but not out pp497 - 499
Carol Potera
10.1038/nbt0507-497
Abstract | Full Text | PDF

Bioentrepreneur

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Building a business

Tapping into foundations pp501 - 504
Linda Nordling
10.1038/bioent918
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Opinion and Comment

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Correspondence

Why the omega-3 piggy should go to market pp505 - 506
Jing X Kang & Alexander Leaf
10.1038/nbt0507-505
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Why the omega-3 piggy should go to market p506
10.1038/nbt0507-506
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Acceptance of GM food[mdash]an experiment in six countries pp507 - 508
John G Knight, Damien W Mather, David K Holdsworth & David F Ermen
10.1038/nbt0507-507
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Compliance costs for regulatory approval of new biotech crops pp509 - 511
Nicholas Kalaitzandonakes, Julian M Alston & Kent J Bradford
10.1038/nbt0507-509
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Commentary

Proposition 71 and CIRM[mdash]assessing the return on investment pp513 - 521
Given that Californian voters authorized state coffers to sell [dollar]3 billion in bonds to fund the California Institute for Regenerative Medicine (CIRM) with the expectation of health and financial benefits, what benchmarks should be used to measure the initiative's success?
Michael T Longaker, Laurence C Baker & Henry T Greely
10.1038/nbt0507-513
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Book Review

Toppling the organic house of cards pp522 - 523
10.1038/nbt0507-522
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Features

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Functional foods from biotech[mdash]an unappetizing prospect? pp525 - 531
In the early 1990s, functional foods promised to solve global malnutrition and put palatable options for treating ailments on grocery shelves. Since then, a meager number of products have ripened while the rest have turned sour.
Kendall Powell
10.1038/nbt0507-525
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Patents

Shortened life spans of biotech pioneer patents in Japan: a lesson from the DNA chip pp533 - 535
Strict examinations have resulted in drastically shortened life spans for a broad range of biotech 'pioneer' patents in Japan.
Tomomi Aida, Atsuo Konishi, Masatoshi Hagiwara & Kazunori Hashimoto
10.1038/nbt0507-533
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Recent patent applications in biological imaging p536
10.1038/nbt0507-536
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News and Views

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Full-length antibodies on display pp537 - 538
Display of IgG libraries on bacteria promises to streamline antibody engineering.
Sachdev S Sidhu
10.1038/nbt0507-537
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See also: Research by Mazor et al.

A welcome diversion from photorespiration pp539 - 540
Suppressing conventional photorespiration in Arabidopsis thaliana increases biomass.
Richard C Leegood
10.1038/nbt0507-539
Full Text | PDF
See also: Research by Kebeish et al.

Metagenomic sorcery and the expanding protein universe pp540 - 542
A metagenomic study of the Atlantic and Pacific oceans reveals dominant bacterial species, remarkable microdiversity and a wealth of new proteins.
Eugene V Koonin
10.1038/nbt0507-540
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Fungal genomics goes industrial pp542 - 543
A functional genomics study of the rice blast fungus unravels the genetic basis of pathogenicity.
Nicholas J Talbot
10.1038/nbt0507-542
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Research Highlights p545
10.1038/nbt0507-545
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Computational Biology

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Perspective

Towards zoomable multidimensional maps of the cell pp547 - 554
Zhenjun Hu, Joe Mellor, Jie Wu, Minoru Kanehisa, Joshua M Stuart & Charles DeLisi
10.1038/nbt1304
Abstract | Full Text | PDF

Research

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Perspective

A risk-based bioanalytical strategy for the assessment of antibody immune responses against biological drugs pp555 - 561
Gopi Shankar, Charles Pendley & Kathryn E Stein
10.1038/nbt1303
Abstract | Full Text | PDF

Brief Communications

Isolation of engineered, full-length antibodies from libraries expressed in Escherichia coli  pp563 - 565
Yariv Mazor, Thomas Van Blarcom, Robert Mabry, Brent L Iverson & George Georgiou
10.1038/nbt1296
First paragraph | Full Text | PDF
See also: News and Views by Sidhu

Quantitative proteomic assessment of very early cellular signaling events pp566 - 568
Joern Dengjel, Vyacheslav Akimov, Jesper V Olsen, Jakob Bunkenborg, Matthias Mann, Blagoy Blagoev & Jens S Andersen
10.1038/nbt1301
First paragraph | Full Text | PDF

Articles

Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus  pp569 - 575
Garry S A Myers, Dane Parker, Keith Al-Hasani, Ruth M Kennan, Torsten Seemann, Qinghu Ren, Jonathan H Badger, Jeremy D Selengut, Robert T DeBoy, Herve Tettelin, John D Boyce, Victoria P McCarl, Xiaoyan Han, William C Nelson, Ramana Madupu, Yasmin Mohamoud, Tara Holley, Nadia Fedorova, Hoda Khouri, Steven P Bottomley, Richard J Whittington, Ben Adler, J Glenn Songer, Julian I Rood & Ian T Paulsen
10.1038/nbt1302
Abstract | Full Text | PDF

A high-quality catalog of the Drosophila melanogaster proteome pp576 - 583
Erich Brunner, Christian H Ahrens, Sonali Mohanty, Hansruedi Baetschmann, Sandra Loevenich, Frank Potthast, Eric W Deutsch, Christian Panse, Ulrik de Lichtenberg, Oliver Rinner, Hookeun Lee, Patrick G A Pedrioli, Johan Malmstrom, Katja Koehler, Sabine Schrimpf, Jeroen Krijgsveld, Floyd Kregenow, Albert J R Heck, Ernst Hafen, Ralph Schlapbach & Ruedi Aebersold
10.1038/nbt1300
Abstract | Full Text | PDF

High-throughput identification of transcription start sites, conserved promoter motifs and predicted regulons pp584 - 592
Patrick T McGrath, Honglak Lee, Li Zhang, Antonio A Iniesta, Alison K Hottes, Meng How Tan, Nathan J Hillson, Ping Hu, Lucy Shapiro & Harley H McAdams
10.1038/nbt1294
Abstract | Full Text | PDF

Chloroplastic photorespiratory bypass increases photosynthesis and biomass production in Arabidopsis thaliana  pp593 - 599
Rashad Kebeish, Markus Niessen, Krishnaveni Thiruveedhi, Rafijul Bari, Heinz-Josef Hirsch, Ruben Rosenkranz, Norma Stabler, Barbara Schonfeld, Fritz Kreuzaler & Christoph Peterhansel
10.1038/nbt1299
Abstract | Full Text | PDF
See also: News and Views by Leegood

Naturejobs

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Careers and Recruitment

Found in translation p601
For those who wish to marry research with clinical applications, finding the right environment can be hard.
David Shaywitz & Hayes Dansky
10.1038/nbt0507-601
Full Text | PDF

People

People p602
10.1038/nbt0507-602
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