Subject: Nature Genetics Contents: October 2006 Vol. 38 pp 1089 - 1220

From: "Nature Genetics Alert"<[email-masked]>
Date: Fri, 13 Oct 2006 09:58:55 -0400 (EDT)

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October 2006, Volume 38 No 10

| Editorial

| Correspondence

| Commentary

| Book Review

| News and Views

| Research Highlights

| Brief Communication

| Articles

| Letters

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This alert is supported by Applied Biosystems

Heredity
Special Issue: Evolutionary Developmental Biology

Evolutionary developmental biology or 'evo-devo' explores the role of genetic variation in the evolution of development processes in animals. This special issue reflects the expansion of this field to consider genetic variation in natural populations in the context of ecologically- relevant evolution of morphologies.

Online access to this Evolutionary Developmental Biology special issue is available at www.nature.com/hdy from September 2006

Nature Reviews Genetics Focus on Statistical Analysis
Research fields as disparate as population genetics and transcription profiling rely on quantitative descriptions, for which statistical analysis tools have become essential. Don’t miss out on this Focus and the accompanying audio supplement, which aim to familiarize readers with the current and debated issues in the statistical analysis of genetic data.

Editorial

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Minimum compliance for a microarray experiment? p1089

doi:10.1038/ng1006-1089

Abstract | Full Text | PDF

Correspondence

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Many hypotheses but no replication for the association between PDE4D and stroke pp1091 - 1092

Jonathan Rosand, Nick Bayley, Natalia Rost & Paul I W de Bakker

doi:10.1038/ng1006-1091

Full Text | PDF

Reply to "Many hypotheses but no replication for the association between PDE4D and stroke" pp1092 - 1093

Jeffrey R Gulcher, Augustine Kong, Gudmar Thorleifsson & Kari Stefansson

doi:10.1038/ng1006-1092

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Commentary

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The genetics of health pp1095 - 1098

Joseph H Nadeau & Eric J Topol

doi:10.1038/ng1006-1095

Abstract | Full Text | PDF

Book Review

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A weed for one year p1099

Reviewed by: Alan Packer

doi:10.1038/ng1006-1099

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News and Views

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Tiling DNA microarrays for fly genome cartography pp1101 - 1102

Brian Oliver

doi:10.1038/ng1006-1101

Abstract | Full Text | PDF

See also: Article by Manak et al.

(Re)modeling the transcriptional enhancer pp1102 - 1103

Marc S Halfon

doi:10.1038/ng1006-1102

Abstract | Full Text | PDF

See also: Article by Janssens et al.

New evidence that DNA encodes its packaging pp1104 - 1105

Sevinc Ercan & Jason D. Lieb

doi:10.1038/ng1006-1104

Abstract | Full Text | PDF

See also: Letter by Ioshikhes et al.

A WNK in the kidney controls blood pressure pp1105 - 1106

Thomas M Coffman

doi:10.1038/ng1006-1105

Abstract | Full Text | PDF

See also: Article by Lalioti et al.

Touching base p1107

doi:10.1038/ng1006-1107

Full Text | PDF

Research Highlights

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Research highlights p1109

doi:10.1038/ng1006-1109

Full Text | PDF

Brief Communication

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Deficiency of hyccin, a newly identified membrane protein, causes hypomyelination and congenital cataract pp1111 - 1113

Federico Zara, Roberta Biancheri, Claudio Bruno, Laura Bordo, Stefania Assereto, Elisabetta Gazzerro, Federica Sotgia, Xiao Bo Wang, Stefania Gianotti, Silvia Stringara, Marina Pedemonte, Graziella Uziel, Andrea Rossi, Angelo Schenone, Paolo Tortori-Donati, Marjo S van der Knaap, Michael P Lisanti & Carlo Minetti

doi:10.1038/ng1870

Abstract | Full Text | PDF

Articles

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Lamin B1 duplications cause autosomal dominant leukodystrophy pp1114 - 1123

Quasar S Padiath, Kazumasa Saigoh, Raphael Schiffmann, Hideaki Asahara, Takeshi Yamada, Anulf Koeppen, Kirk Hogan, Louis J Ptacek & Ying-Hui Fu

doi:10.1038/ng1872

Abstract | Full Text | PDF

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule pp1124 - 1132

Maria D Lalioti, Junhui Zhang, Heather M Volkman, Kristopher T Kahle, Kristin E Hoffmann, Hakan R Toka, Carol Nelson-Williams, David H Ellison, Richard Flavell, Carmen J Booth, Yin Lu, David S Geller & Richard P Lifton

doi:10.1038/ng1877

Abstract | Full Text | PDF

See also: News and Views by Coffman

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53 pp1133 - 1141

Daniele Bergamaschi, Yardena Samuels, Alexandra Sullivan, Marketa Zvelebil, Hilde Breyssens, Andrea Bisso, Giannino Del Sal, Nelofer Syed, Paul Smith, Milena Gasco, Tim Crook & Xin Lu

doi:10.1038/ng1879

Abstract | Full Text | PDF

Delineation of a Fat tumor suppressor pathway pp1142 - 1150

Eunjoo Cho, Yongqiang Feng, Cordelia Rauskolb, Sushmita Maitra, Rick Fehon & Kenneth D Irvine

doi:10.1038/ng1887

Abstract | Full Text | PDF

Biological function of unannotated transcription during the early development of Drosophila melanogaster  pp1151 - 1158

J Robert Manak, Sujit Dike, Victor Sementchenko, Philipp Kapranov, Frederic Biemar, Jeff Long, Jill Cheng, Ian Bell, Srinka Ghosh, Antonio Piccolboni & Thomas R Gingeras

doi:10.1038/ng1875

Abstract | Full Text | PDF

See also: News and Views by Oliver

Quantitative and predictive model of transcriptional control of the Drosophila melanogaster even skipped gene pp1159 - 1165

Hilde Janssens, Shuling Hou, Johannes Jaeger, Ah-Ram Kim, Ekaterina Myasnikova, David Sharp & John Reinitz

doi:10.1038/ng1886

Abstract | Full Text | PDF

See also: News and Views by Halfon

Letters

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A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC pp1166 - 1172

Paul I W de Bakker, Gil McVean, Pardis C Sabeti, Marcos M Miretti, Todd Green, Jonathan Marchini, Xiayi Ke, Alienke J Monsuur, Pamela Whittaker, Marcos Delgado, Jonathan Morrison, Angela Richardson, Emily C Walsh, Xiaojiang Gao, Luana Galver, John Hart, David A Hafler, Margaret Pericak-Vance, John A Todd, Mark J Daly, John Trowsdale, Cisca Wijmenga, Tim J Vyse, Stephan Beck, Sarah Shaw Murray, Mary Carrington, Simon Gregory, Panos Deloukas & John D Rioux

doi:10.1038/ng1885

Abstract | Full Text | PDF

A common CFH haplotype, with deletion of CFHR1 and CFHR3 , is associated with lower risk of age-related macular degeneration pp1173 - 1177

Anne E Hughes, Nick Orr, Hossein Esfandiary, Martha Diaz-Torres, Timothy Goodship & Usha Chakravarthy

doi:10.1038/ng1890

Abstract | Full Text | PDF

Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer pp1178 - 1183

Tsun Leung Chan, Siu Tsan Yuen, Chi Kwan Kong, Yee Wai Chan, Annie SY Chan, Wai Fu Ng, Wai Yin Tsui, Michelle WS Lo, Wing Yip Tam, Vivian SW Li & Suet Yi Leung

doi:10.1038/ng1866

Abstract | Full Text | PDF

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase pp1184 - 1191

Alfredo Ramirez, Andre Heimbach, Jan Grundemann, Barbara Stiller, Dan Hampshire, L Pablo Cid, Ingrid Goebel, Ammar F Mubaidin, Abdul-Latif Wriekat, Jochen Roeper, Amir Al-Din, Axel M Hillmer, Meliha Karsak, Birgit Liss, C Geoffrey Woods, Maria I Behrens & Christian Kubisch

doi:10.1038/ng1884

Abstract | Full Text | PDF

Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking pp1192 - 1197

Simeon A Boyadjiev, J Christopher Fromme, Jin Ben, Samuel S Chong, Christopher Nauta, David J Hur, George Zhang, Susan Hamamoto, Randy Schekman, Mariella Ravazzola, Lelio Orci & Wafaa Eyaid

doi:10.1038/ng1876

Abstract | Full Text | PDF

Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation pp1198 - 1203

Michael R Lang, Lynne A Lapierre, Michael Frotscher, James R Goldenring & Ela W Knapik

doi:10.1038/ng1880

Abstract | Full Text | PDF

Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus pp1204 - 1209

Kevin Lee, JaeWook Jeong, Inseok Kwak, Cheng-Tai Yu, Beate Lanske, Desi W Soegiarto, Rune Toftgard, Ming-Jer Tsai, Sophia Tsai, John P Lydon & Francesco J DeMayo

doi:10.1038/ng1874

Abstract | Full Text | PDF

Nucleosome positions predicted through comparative genomics pp1210 - 1215

Ilya P Ioshikhes, Istvan Albert, Sara J Zanton & B Franklin Pugh

doi:10.1038/ng1878

Abstract | Full Text | PDF

See also: News and Views by Ercan and Lieb

Mammalian ultraconserved elements are strongly depleted among segmental duplications and copy number variants pp1216 - 1220

Adnan Derti, Frederick P Roth, George M Church & C-ting Wu

doi:10.1038/ng1888

Abstract | Full Text | PDF

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