Subject: Leica AF6000 Series: New Features for Real Dynamic Imaging!

From: "Nature Publishing Group"<[email-masked]>
Date: Thu, 12 Oct 2006 15:19:25 -0400 (EDT)

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New Features with the Leica AF6000 Series for Real Dynamic Fluorescence Imaging

• Live Data Mode - for advanced time lapse experiments
• External Filter Wheels - for high speed filter changing
• Leica AM TIRF - for the study of cellular membranes

Dear Nature Reader,

The Leica AF6000 widefield series - our family of modular and upgradeable systems to suit all fluorescence imaging requirements - is available with a range of additional accessories and options for advanced fluorescence imaging. Seamless integration into the AF6000 range, give truly enhanced performance of the system for specific applications including Total Internal Reflection Fluorescence (TIRF) and Fluorescence Resonance Energy Transfer (FRET). In addition, the high demands of live cell imaging can be met with the Leica Live Data Mode application module, intuitive software that aids in the design of advanced time lapse experiments.

Speed is of the essence when imaging live cells, as dynamic processes require fast system responses - not just for image acquisition but in many applications, changing the wavelength of light. The Leica external filter wheel module, can be fitted to our advanced research inverted microscopes to offer high speed filter changing with a range of filter sets to match specific applications.

Total Internal Reflection Fluorescence microscopy is the ideal technique for the study of cellular membranes and their environment. The new Leica TIRF solution uses a feedback loop for highly accurate positioning of the laser. This allows changes in the penetration depths or even the direction of the evanescence field at the click of a button. The Leica AM TIRF system, with the Leica AF6000 at its core, gives a substantially improved signal-to-noise ratio, for the highest quality results in advanced fluorescence imaging.

You never know what will happen during the course of a live cell experiment, so full flexibility to change parameters in an instant, is a must. The Leica Live Data Mode module allows you to interactively monitor, log and change system behaviour, in response to what's happening during your experiment. The result is real dynamic imaging!

To learn more about the Leica AF6000 Series go to www.leica-microsystems.com/AF6000series

Live Data Mode

Leica External Filter Wheel

Leica AM TIRF

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