Subject: Nature Reviews Molecular Cell Biology contents October 2006 Volume 7 Number 10 pp703 - 788

From: "Nature Reviews Molecular Cell Biology Alert"<[email-masked]>
Date: Mon, 25 Sep 2006 05:13:32 -0400 (EDT)

TABLE OF CONTENTS

October 2006 Volume 7 Number 10

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In this issue
Research Highlights
Reviews
Perspectives

Also this month
Article series:
Mechanisms of disease

Also this month
Featured article:
The ARP2/3 complex: an actin nucleator comes of age
Erin D. Goley and Matthew D. Welch

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Nature Reviews Molecular Cell Biology - Article Series on Mechanisms of disease

To design successful treatments, we first have to understand the molecular and cellular mechanisms that underlie different diseases, so to find out more, we suggest you check out the Nature Reviews Molecular Cell Biology Series of articles on Mechanisms of disease, which launched in June 2006 and will run into 2007.

Find out more

From the Editors
p703 | 10.1038/nrm2038

RESEARCH HIGHLIGHTS

Top

Gene regulation: Welded on the spot
Arianne Heinrichs
p705 | 10.1038/nrm2033

Mechanisms of disease: Perils of ageing
Asher Mullard
Published online: 13 September 2006
p706 | 10.1038/nrm2029

Mitosis: Give us a kiz
Monica Hoyos Flight
p706 | 10.1038/nrm2032

Imaging: Overcoming the barrier
Arianne Heinrichs
Published online: 13 September 2006
p707 | 10.1038/nrm2027

Ageing: Balancing self-renewal and ageing
Ekat Kritikou
p708 | 10.1038/nrm2036

TECHNOLOGY WATCH
Nanoscale microscopy goes green | Stochastic imaging
p709 | 10.1038/nrm2034

Chromatin: Eukaryotic genomes in complete control
Magdalena Skipper
p709 | 10.1038/nrm2035

Chromatin: The yin and yang...
Shannon Amoils
Published online: 13 September 2006
p710 | 10.1038/nrm2028

Membrane trafficking: Kiss and patch up
James Pickett
p710 | 10.1038/nrm2031

IN THE NEWS
Hitting junk
Ekat Kritikou
p710 | 10.1038/nrm2040

IN BRIEF
Cell cycle | Nuclear transport | Cell polarity
p711 | 10.1038/nrm2037

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REVIEWS

Top

The ARP2/3 complex: an actin nucleator comes of age
Erin D. Goley & Matthew D. Welch
p713 | 10.1038/nrm2026
The ARP2/3 complex regulates the initiation of actin polymerization and the organization of filaments into y-branched networks. Recent studies have begun to reveal the role of this complex in diverse cellular processes and its molecular mechanisms of action, as well as its misregulation during disease.
Abstract | Full Text | PDF

The COPII cage: unifying principles of vesicle coat assembly
Cemal Gurkan, Scott M. Stagg, Paul LaPointe & William E. Balch
p727 | 10.1038/nrm2025
Recent studies of the early secretory pathway have analysed cargo selection and transport-carrier formation by components of the endoplasmic-reticulum-associated coat protein complex-II (COPII). Results are indicative of a unifying model of cage and coat function in vesicle and tubule formation as well as fission in endomembrane traffic.
Abstract | Full Text | PDF | Supplementary information

Mechanism of homologous recombination: mediators and helicases take on regulatory functions
Patrick Sung & Hannah Klein
Published online: 23 August 2006
p739 | 10.1038/nrm2008
Homologous recombination has an important role in DNA repair, DNA replication, meiotic chromosome segregation and telomere maintenance. Its tight regulation by DNA helicases and mediator proteins is essential to avoid cell-cycle arrest, genome destabilization and cancer formation.
Abstract | Full Text | PDF

The replication clamp-loading machine at work in the three domains of life
Chiara Indiani & Mike O'Donnell
Published online: 06 September 2006
p751 | 10.1038/nrm2022
Processive DNA polymerases that replicate chromosomes interact with a ring-shaped clamp that encircles DNA and slides along the duplex. The sliding clamp is loaded onto DNA by a clamp-loader complex. Structural and biochemical studies have provided mechanistic insights into the clamp-loading process.
Abstract | Full Text | PDF

Article series: Mechanisms of disease
Molecular mechanisms of muscular dystrophies: old and new players
Kay E Davies & Kristen J Nowak
Published online: 13 September 2006
p762 | 10.1038/nrm2024
The study of muscular dystrophies has shown that mutant proteins result in perturbations of many cellular components. These findings have revealed important insights for cell biologists, and have also identified unexpected and exciting new approaches for therapy.
Abstract | Full Text | PDF | Supplementary information

PERSPECTIVES

Top

INNOVATION
A chemical toolkit for proteins — an expanded genetic code
Jianming Xie & Peter G. Schultz
Published online: 23 August 2006
p775 | 10.1038/nrm2005
Recently, a method was developed to encode unnatural amino acids genetically in bacteria, yeast and mammalian cells. This provides a powerful tool for exploring protein structure and function in vitro and in vivo, and for generating proteins with new or enhanced properties.
Abstract | Full Text | PDF

OPINION
SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton
Yonatan B. Tzur, Katherine L. Wilson & Yosef Gruenbaum
Published online: 23 August 2006
p782 | 10.1038/nrm2003
The SUN-domain family of nuclear envelope proteins interacts with KASH-domain proteins, which are also nuclear envelope proteins, to form 'bridges' across the inner and outer nuclear membranes. SUN-domain proteins are now proposed to provide a mechanical connection between the nucleoskeleton and the cytoskeleton.
Abstract | Full Text | PDF

Announcing Nature Methods user's guide to RNA interference

A uniquely matter-of-fact guide on critical aspects of using RNA interference in mammalian systems.

Read this special focus in the September 2006 issue of Nature Methods or access it free online through November.

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*Journal Citation Reports, Thomson, 2006

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