Subject: Nature Reviews Genetics contents October 2006 Volume 7 Number 10, pp737 - 820

From: "Nature Reviews Genetics Alert"<[email-masked]>
Date: Thu, 21 Sep 2006 05:17:54 -0400 (EDT)

TABLE OF CONTENTS

October 2006 Volume 7 Number 10

This alert is sponsored by Roche Applied Science

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In this issue
Research Highlights
Focus on: Statistical Analysis
Reviews
Perspectives
Correspondence

Also this month
Featured article:
Spreading of silent chromatin: inaction at a distance
Paul B. Talbert and Steven Henikoff

Nature Reviews Genetics Focus on Statistical Analysis

Research fields as disparate as population genetics and transcription profiling rely on quantitative descriptions, for which statistical analysis tools have become essential. Don't miss out on this Focus and the accompanying audio supplement, which aim to familiarize readers with the current and debated issues in the statistical analysis of genetic data.

From the editors
p737 | 10.1038/nrg1963

RESEARCH HIGHLIGHTS

Top

Stem cells: A recipe for reprogramming
Louisa Flintoft
p738 | 10.1038/nrg1977

Transcriptomics: Every transcript counts
Patrick Goymer
p739 | 10.1038/nrg1973

RNA interference: RNAi misses the target
Patrick Goymer
p739 | 10.1038/nrg1974

Evolution: Jump-starting speciation
Louisa Flintoft
p740 | 10.1038/nrg1975

Reproductive Biology: From worm sperm proteins to human infertility
Tanita Casci
p740 | 10.1038/nrg1976

IN BRIEF
Development | Gene function | Plant biology | Cancer genetics
p741 | 10.1038/nrg1978

Chromatin: Eukaryotic genomes in complete control
Magdalena Skipper
Published online: 30 August 2006
p742 | 10.1038/nrg1966

Ageing: Longevity mutations inhibit tumours
Patrick Goymer
Published online: 12 September 2006
p742 | 10.1038/nrg1972

Evolution: Putting flower colour on the landscape
Tanita Casci
Published online: 05 September 2006
p743 | 10.1038/nrg1971

Human genetics: INDELible markers
Edward Wawrzynczak
Published online: 30 August 2006
p744 | 10.1038/nrg1965

IN BRIEF
Epigenetics | Technology | Population genetics | Development
p744 | 10.1038/nrg1979

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Focus on: Statistical Analysis

REVIEWS

Top

Computer programs for population genetics data analysis: a survival guide
Laurent Excoffier & Gerald Heckel
Published online: 22 August 2006
p745 | 10.1038/nrg1904
The increase in population genetics data has led to a parallel need for sophisticated analysis programs and packages. This article is intended as a guide to many of these statistical programs, to promote their more informed use.
Abstract | Full Text | PDF

Modern computational approaches for analysing molecular genetic variation data
Paul Marjoram & Simon Tavaré
p759 | 10.1038/nrg1961
The vast increase in the amount of molecular genetic data that are being generated, and the scale of their complexity, demand ever more sophisticated statistical analysis methods — this article surveys and compares these approaches, and the growing reliance on computational methodologies.
Abstract | Full Text | PDF

Genetic relatedness analysis: modern data and new challenges
Bruce S. Weir, Amy D. Anderson & Amanda B. Hepler
p771 | 10.1038/nrg1960
The concept of relatedness is central to many fields, from human linkage analysis to forensics to animal and plant breeding. This review covers the statistical framework for studying relatedness, its applications and the challenges that the field faces.
Abstract | Full Text | PDF | Supplementary information

A tutorial on statistical methods for population association studies
David J. Balding
p781 | 10.1038/nrg1916
Identifying polymorphisms that are overrepresented in disease cases versus controls would seem to be a straightforward process, but genetic association studies are notoriously riddled with complex analysis problems. This article outlines these statistical issues and provides some guidance to overcoming them.
Abstract | Full Text | PDF | Supplementary information

REVIEWS

Top

Spreading of silent chromatin: inaction at a distance
Paul B. Talbert & Steven Henikoff
p793 | 10.1038/nrg1920
Several models have been proposed to explain the spreading of heterochromatin, including looping, sliding and oozing. A review of studies from diverse model eukaryotes allows the authors to evaluate the existing models and leads them to propose a common, ancestral mechanism for spreading.
Abstract | Full Text | PDF

PERSPECTIVES

Top

INNOVATION
TAR cloning: insights into gene function, long-range haplotypes and genome structure and evolution
Natalay Kouprina & Vladimir Larionov
p805 | 10.1038/nrg1943
Transformation-associated recombination (TAR) cloning uses in vivo recombination in yeast to isolate large chromosomal segments from complex genomes. Although the principles of TAR cloning date back to the 1990s, recent modifications have opened up promising new applications of this technology.
Abstract | Full Text | PDF

OPINION
Genes, environment and the value of prospective cohort studies
Teri A. Manolio, Joan E. Bailey-Wilson & Francis S. Collins
p812 | 10.1038/nrg1919
Gene-environment interactions are key contributors to complex disease, but are hard to dissect in commonly used case-control designs. This article argues that large-scale prospective cohort studies, several of which are planned or under way, provide an essential alternative strategy.
Abstract | Full Text | PDF

CORRESPONDENCE

Top

Correspondence: Mining meiosis with genomic models
R. M. Ranganath & G. Venkatachalaiah
Published online: 01 September 2006
10.1038/nrg1614-c1
Full Text | PDF

Erratum: Evolutionary genetics: High-resolution mutation mapping reveals parallel experimental evolution in yeast
p 744| 10.1038/nrg1980
Full Text | PDF

Heredity

Special Issue: Evolutionary Developmental Biology

Evolutionary developmental biology or 'evo-devo' explores the role of genetic variation in the evolution of development processes in animals. This special issue reflects the expansion of this field to consider genetic variation in natural populations in the context of ecologically- relevant evolution of morphologies.

Online access to this Evolutionary Developmental Biology special issue is available at www.nature.com/hdy from September 2006

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*Journal Citation Reports, Thomson, 2006

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