Subject: Drug [email-masked] 11 August 2006

From: "Drug Discovery"<[email-masked]>
Date: Fri, 11 Aug 2006 05:39:08 -0400 (EDT)

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11 August 2006 Issue

Horizon Symposia

News

Research highlights

Research & reviews

Market analysis

Naturejobs drug discovery

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| News |

Club drug finds use as antidepressant
Psychedelic ketamine hits the blues surprisingly fast.

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Silent running: the race to the clinic
A technique for turning genes off has sparked a flurry of biotech investment.

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AIDS vaccine research becomes 'big science'
But 'mission-oriented' approach has its critics.

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AIDS treatment: Staying the course
Some feared that widespread use of AIDS treatments in Africa would encourage drug resistance, with globally disastrous consequences. But there's no crisis yet.

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more news

| Research highlights |

RNA interference: Targeted delivery by an RNA double
Two methods could overcome the delivery problems of siRNAs

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Asthma and allergy: TSLP aids memory
Cells identified that could help maintain and reactivate memory cells in allergic disease.

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Oncogenomics: Cross-species comparisons
Genomics identifies oncogenes in liver cancer.

more research highlights

| Market analysis |

From the analyst's couch: Anaemia therapies
Successful commercialization of new drugs by a small company will probably require partnering with larger players.

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Fresh from the pipeline: Quadrivalent human papillomavirus recombinant vaccine
First vaccine for the prevention of cervical cancer approved.

more market analysis articles

| Research & reviews |

Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
The truth on how sildenafil evolved from a potential angina treatment to a blockbuster drug for erectile dysfunction and beyond.

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Global mapping of pharmacological space
Integrating several sources of medicinal chemistry data provides a framework for increasing research productivity.

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Drug penetration in solid tumours
How to overcome one of the biggest barriers in cancer treatment.

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Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
Potential problems for cancer wonder drug.

more research & reviews

| Naturejobs drug discovery |

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Simon Campbell
The ex-research head of Pfizer discusses why bigger isn’t necessarily better for R&D productivity.

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