Subject: Nature Contents: 27 July 2006 Volume 442 Number 7101, pp329-484

From: "NatureAlert"<[email-masked]>
Date: Wed, 26 Jul 2006 15:36:40 -0400 (EDT)

TABLE OF CONTENTS

Volume 442 Number 7101 pp329-484

This alert is sponsored by Biacore

In this issue
Authors
Editorials
Research Highlights
News
Business
News Features
Correspondence
Books and Arts
News and Views
Insight
Article
Letters
Naturejobs
Futures

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Editor's summary
Authors
Nature Podcast
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Editorials

Top

Come veto or high water p329
The obduracy of the White House will slow the progress of stem-cell research in the United States — just as Europe agrees to move forward with it.
10.1038/442329a
Full Text | PDF

Still not alert p330
Tsunami preparations in the Indian Ocean remain inadequate.
10.1038/442330a
Full Text | PDF

Let's replicate p330
Post-publication follow-up evolves.
10.1038/442330b
Full Text | PDF

Research Highlights

Top

Research highlights p332
10.1038/442332a
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News

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Nigeria ready for huge science spend p334
Oil revenues set to establish national research foundation.
Jim Giles
10.1038/442334a
Full Text | PDF

A long week in stem-cell politics... p335
Europe and the United States still divided over embryo cells.
Meredith Wadman and Alison Abbott
10.1038/442335a
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The lure of stem-cell lines p336
Nature investigates what human embryonic stem-cell lines have been derived worldwide so far, and why scientists are so desperate to work with new ones.
10.1038/442336a
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Wildlife caught in crossfire of US immigration battle p338
Crackdown on illegal border crossings puts endangered species at further risk.
Emma Marris
10.1038/442338a
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Sidelines p339
10.1038/442339a
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Carbon credits for the Joneses p340
UK politician advocates domestic emissions allowance.
Jim Giles
10.1038/442340a
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Business

Top

Break with tradition p342
Traditional medicine has spent decades in the wings of pharmacology. Now India is pushing it to centre stage, as K. S. Jayaraman reports.
10.1038/442342a
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In brief p343
10.1038/442343a
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Market watch p343
10.1038/442343b
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News Features

Top

The trouble with replication p344
The idea that readers should be able to replicate published scientific results is seen as the bedrock of modern science. But what if replication proves difficult or impossible? Jim Giles tracks the fate of one group of papers.
10.1038/442344a
Full Text | PDF
See also: Editor's summary

Bird flu: On border patrol p348
The United States has embarked on a huge effort to try to track the H5N1 avian flu virus in birds migrating into the country. But is surveillance more urgently needed elsewhere? Erika Check reports.
10.1038/442348a
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Lab on a chip: A little goes a long way p351
Faster, safer and easier to control — chemical reactions in microreactors are taking off in the lab. Now industry is being seduced by the charms of the lab on a chip. Jenny Hogan investigates.
10.1038/442351a
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Correspondence

Top

Hungary: academy is not obsolete or discriminatory p353
Gyorgy Fabri
10.1038/442353a
Full Text | PDF

Hungary: academy needs more than internal reform p353
Csaba Szabo
10.1038/442353b
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Quest for seed immortality is mission impossible p353
Andreas Graner and Andreas Borner
10.1038/442353c
Full Text | PDF

No place for secrets in scientific research p353
Clifford B. Saper
10.1038/442353d
Full Text | PDF

Books and Arts

Top

Design flaws p355
Destroying the argument that intelligent design has a scientific basis.
John Tyler Bonner reviews Intelligent Thought: Science Versus the Intelligent Design Movement edited by John Brockman
10.1038/442355a
Full Text | PDF
See also: Editor's summary

Diary of a weed p356
Anthony Trewavas reviews Seed to Seed: The Secret Life of Plants by Nicholas Harberd
10.1038/442356a
Full Text | PDF

The body bared p356
Human Anatomy: Depicting the Body from the Renaissance to Today by Benjamin A. Rifkin, Michael J. Ackerman and Judy Folkenberg
10.1038/442356b
Full Text | PDF

Playing the numbers game p357
David Colquhoun reviews Does Measurement Measure Up? How Numbers Reveal and Conceal the Truth by John M. Henshaw
10.1038/442357a
Full Text | PDF

News and Views

Top

Semiconductor physics: Magnetic manipulations p359
A deft technique allows magnetic atoms to be placed one by one in a semiconductor crystal. It's a further step towards an ambitious goal: a computer chip that might simultaneously store and manipulate data.
Nitin Samarth
10.1038/442359a
Full Text | PDF
See also: Editor's summary

Protein folding: Inside the cage p360
Many newly synthesized bacterial proteins avoid aggregation by folding inside a chaperonin nanocage. Unexpectedly, it turns out that the cage's internal properties can be optimized to accelerate folding.
R. John Ellis
10.1038/442360a
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50 & 100 years ago p361
10.1038/442361a
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Planetary science: Titan's exotic weather p362
Titan is viewed as a sibling of Earth, as both bodies have rainy weather systems and landscapes formed by rivers. But as we study these similarities, Titan emerges as an intriguingly foreign world.
Caitlin A. Griffith
10.1038/442362a
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See also: Editor's summary

Developmental biology: The hole picture p363
What's the best way to make a tube? Roll up a sheet? Hollow out a solid rod? Some innovative movies show how the problem is tackled during the development of blood vessels in embryos.
Keith Mostov and Fernando Martin-Belmonte
10.1038/442363a
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See also: Editor's summary

Astronomy: Revealing flares p364
Transient bursts of cosmic light provide a unique window on what's going on in the distant Universe. But similar bursts closer to home may be muddying the view, and hopes rest on a new tool to resolve things.
J. Anthony Tyson
10.1038.442364a
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Developmental neurobiology: A destructive switch for neurons p365
In the developing nervous system, tremendous multiplication and diversification of cells elaborate the exquisite pattern of the brain. But how do cells shift from early proliferation to assume their mature states?
Peter K. Jackson
10.1038/442365a
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Insight: Lab on a chip FREE ACCESS

Lab on a chip p367
Rosamund Daw and Joshua Finkelstein
10.1038/442367a
Full Text | PDF

The origins and the future of microfluidics p368
George M. Whitesides
10.1038/nature05058
Abstract | Full Text | PDF

Scaling and the design of miniaturized chemical-analysis systems p374
Dirk Janasek, Joachim Franzke and Andreas Manz
10.1038/nature05059
Abstract | Full Text | PDF

Developing optofluidic technology through the fusion of microfluidics and optics p381
Demetri Psaltis, Stephen R. Quake and Changhuei Yang
10.1038/nature05060
Abstract | Full Text | PDF

Future lab-on-a-chip technologies for interrogating individual molecules p387
Harold Craighead
10.1038/nature05061
Abstract | Full Text | PDF

Control and detection of chemical reactions in microfluidic systems p394
Andrew J. deMello
10.1038/nature05062
Abstract | Full Text | PDF

Cells on chips p403
Jamil El-Ali, Peter K. Sorger and Klavs F. Jensen
10.1038/nature05063
Abstract | Full Text | PDF

Microfluidic diagnostic technologies for global public health p412
Paul Yager et al.
10.1038/nature05064
Abstract | Full Text | PDF

Article

Top

Snapshots of tRNA sulphuration via an adenylated intermediate p419
Molecular 'snapshots' of the MnmA thiouridylase-tRNA complex reveal that during RNA sulphuration, a key α-helix forms around the active site, burying U34 into the catalytic pocket. This 'closed' conformation of the active site ensures that sulphur is incorporated into uridine at the correct place.
Tomoyuki Numata et al.
10.1038/nature04896
Abstract | Full Text | PDF
See also: Editor's summary

Letters

Top

A low fraction of nitrogen in molecular form in a dark cloud p425
Analysis of the N2H+ — and, by inference, the N2 — abundance inside a cold dark molecular cloud finds that most of the nitrogen is atomic, rather than molecular, explaining the low N2 abundance in comets.
S. Maret, E. A. Bergin and C. J. Lada
10.1038/nature04919
First paragraph | Full Text | PDF
See also: Editor's summary

Methane storms on Saturn's moon Titan p428
Calculations show that severe methane convective storms accompanied by intense precipitation may occur on Titan under the right environmental conditions. Such rainfalls on Titan's surface are comparable to flash flood events on Earth.
R. Hueso and A. Sánchez-Lavega
10.1038/nature04933
First paragraph | Full Text | PDF
See also: Editor's summary | News and Views by Griffith

Methane drizzle on Titan p432
In situ data from Saturn's moon Titan indicates an upper methane ice cloud and a lower, barely visible, liquid methane-nitrogen cloud, with a gap in between. The lower liquid cloud produces drizzle that reaches Titan's surface.
Tetsuya Tokano et al.
10.1038/nature04948
First paragraph | Full Text | PDF
See also: Editor's summary | News and Views by Griffith

Atom-by-atom substitution of Mn in GaAs and visualization of their hole-mediated interactions p436
Dale Kitchen et al.
10.1038/nature04971
First paragraph | Full Text | PDF
See also: Editor's summary | News and Views by Samarth

Widespread active detachment faulting and core complex formation near 13° N on the Mid-Atlantic Ridge p440
Deborah K. Smith, Johnson R. Cann and Javier Escartin
10.1038/nature04950
First paragraph | Full Text | PDF

A ubiquitous thermoacidophilic archaeon from deep-sea hydrothermal vents p444
Isolation and cultivation of an extreme thermoacidophilic archaeon from hydrothermal vents suggests that this organism may be important in the iron and sulphur cycles in these environments.
Anna-Louise Reysenbach et al.
10.1038/nature04921
First paragraph | Full Text | PDF
See also: Editor's summary

Strategies for mitigating an influenza pandemic p448
Neil M. Ferguson et al.
10.1038/nature04795
First paragraph | Full Text | PDF
See also: Editor's summary

Endothelial tubes assemble from intracellular vacuoles in vivo p453
High-resolution time-lapse imaging from zebrafish shows that the lumen of blood vessels is formed by coalescence of intracellular vacuoles, followed by fusion to the plasma membrane.
Makoto Kamei et al.
10.1038/nature04923
First paragraph | Full Text | PDF
See also: Editor's summary | News and Views by Mostov Martin-Belmonte

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN p457
Electric fields are shown to act as directional cues for cell migration during wound healing, and the signalling pathways involved are elucidated.
Min Zhao et al.
10.1038/nature04925
First paragraph | Full Text | PDF
See also: Editor's summary

IL-23 promotes tumour incidence and growth p461
John L. Langowski et al.
10.1038/nature04808
First paragraph | Full Text | PDF
See also: Editor's summary

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination p466
Examination of the role of the ATM protein in oncogenic chromosomal translocations in the disease ataxia telangiectasia finds that ATM is involved directly in stabilizing a complex that occurs when DNA double-strand breaks are made in lymphocyte antigen receptor loci. When the complex is not stabilized, the DNA ends are able to undergo aberrant reactions that can lead to translocations.
Andrea L. Bredemeyer et al.
10.1038/nature04866
First paragraph | Full Text | PDF

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth p471
The anaphase-promoting complex/cyclosome (APC/C) has a key role in controlling mitosis. This paper identifies Id2 as a target of the APC/C that is responsible for its function in regulating axonal growth.
Anna Lasorella et al.
10.1038/nature04895
First paragraph | Full Text | PDF
See also: News and Views by Jackson

Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography p475
Cryo-electron tomography was used to produce a three-dimensional model of sea urchin sperm microtubule doublets with a resolution sufficient to identify tubulin as well as other components — such as tektins that form a filament inside the A-tubule of the doublet.
Haixin Sui and Kenneth H. Downing
10.1038/nature04816
First paragraph | Full Text | PDF

Naturejobs

Top

Prospect
Prospects p479
Looking for the best way to balance lab life and family.
Paul Smaglik
10.1038/nj7101-479a
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Special Report
Trial blazers p480
The drug industry may be going through lean times, as new candidates have to clear ever-higher safety hurdles. But this gives scientists who can steer a drug through clinical trials a head start in the job market, says Hannah Hoag.
Hannah Hoag
10.1038/nj7101-480a
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Matthias Kleiner, president, DFG, Bonn, Germany p482
Matthias Kleiner is first engineer to head Germany's DFG.
Friederike Siegel
10.1038/nj7101-482a
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Where are the physician-scientists? p482
Physician-scientists wanted.
Alfredo Quiñones-Hinojosa
10.1038/nj7101-482b
Full Text | PDF

Lab makeover p482
Giving the lab a new look.
Milan de Vries
10.1038/nj7101-482c
Full Text | PDF

Futures

Top

Golden year p484
The gift of memories.
Igor Teper
10.1038/442484a
Full Text | PDF

Advance Online Publication

Top

26 July 2006
LETTERS
Microstimulation of inferotemporal cortex influences face categorization
Seyed-Reza Afraz et al.
doi: 10.1038/nature04982
Abstracts | Full Text | PDF | Supplementary information

26 July 2006
The nitrate/proton antiporter AtCLCa mediates nitrate accumulation in plant vacuoles
A. De Angeliet al.
doi: 10.1038/nature05013
Abstracts | Full Text | PDF | Supplementary information

26 July 2006
Evidence that mechanisms of fin development evolved in the midline of early vertebrates
Renata Freitas et al.
doi: 10.1038/nature04935
Abstracts | Full Text | PDF | Supplementary information

26 July 2006
NEWS AND VIEWS
Neuroscience: Making faces in the brain
James J. DiCarlo
doi: 10.1038/nature05000
Full Text | PDF

26 July 2006
Physiology: Nitrate at the ion exchange
Julian I. Schroeder
doi: 10.1038/nature04999
Full Text | PDF

23 July 2006
LETTERS
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
Ivo C. Lorenz et al.
doi: 10.1038/nature04975
Abstracts | Full Text | PDF | Supplementary information

23 July 2006
Protein flexibility acclimatizes photosynthetic energy conversion to the ambient temperature
Oksana Shlyk-Kerner et al.
doi: 10.1038/nature04947
Abstracts | Full Text | PDF | Supplementary information

Nature Reviews Molecular Cell Biology — Modification-dependent interactions Poster — free online access

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