Subject: Nature Biotechnology Contents: September 2006 Volume 24 pp. 1039 - 1176

From: "Nature Biotechnology"<[email-masked]>
Date: Wed, 13 Sep 2006 11:16:39 -0400 (EDT)

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September 2006, Volume 24 No 9

| In This Issue

| Focus

| Editorials

| News: In Brief | Data Page | News Feature

| Bioentrepreneur: Building a business

| Opinion and Comment: Correspondence | Commentary | Investor's Lab

| Features: Patents

| News and Views

| Foreword

| Opinion and Comment: Commentary

| Research: Analysis | Articles

| Errata

| Corrigenda

| Retraction

| Naturejobs: Careers and Recruitment | People

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In This Issue

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Focus

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Microarray Quality Control
This focus presents the first formal results of the MicroArray Quality Control (MAQC) project, an unprecedented, community-wide effort, under the auspices of the FDA, with the goal of experimentally addressing the key issues surrounding the reliability of DNA microarray data and establishing operational metrics to objectively assess the performance of seven microarray platforms. Ultimately, it is hoped that the MAQC effort will provide the research and regulatory communities with a foundation from which to derive the necessary guidelines for using microarrays in clinical practice and regulatory decision-making.

Editorials

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Making the most of microarrays p1039

doi:10.1038/nbt0906-1039

Abstract | Full Text | PDF

Can Europe accelerate out of trouble? p1040

doi:10.1038/nbt0906-1040

Abstract | Full Text | PDF

News

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Companies eye slice of age-related macular degeneration market pp1041 - 1042

Emily Waltz

doi:10.1038/nbt0906-1041

Abstract | Full Text | PDF

New clinical trials policy at FDA p1043

Brian Vastag

doi:10.1038/nbt0906-1043

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Amgen's TPO mimic faces stiff competition p1044

Stacy Lawrence

doi:10.1038/nbt0906-1044

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BioXell: an Italian biotech success story? pp1045 - 1046

Cormac Sheridan

doi:10.1038/nbt0906-1045

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In Brief

News In Brief pp1048 - 1049

doi:10.1038/nbt0706-1048

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Profile: Abe Abuchowski p1050

Alla Katsnelson

doi:10.1038/nbt0906-1050

Abstract | Full Text | PDF

Data Page

Biotech R&D goes further afield p1052

Stacey Lawrence

doi:10.1038/nbt0906-1052

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News Feature

Systems Biology, Incorporated? pp1055 - 1057

Karl Thiel

doi:10.1038/nbt0906-1055

Abstract | Full Text | PDF

Clinical trial data: to disclose or not to disclose? pp1058 - 1060

Aaron Bouchie

doi:10.1038/nbt0906-1058

Abstract | Full Text | PDF

Bioentrepreneur

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Building a business

The promise of the East: India and China as R&D options pp1061 - 1064

Simon Goodall, Bart Janssens, Kim Wagner, John Wong, Wendy Woods & Michael Yeh

doi:10.1038/bioent910

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Opinion and Comment

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Correspondence

How to stay out of a BIND p1065

William B Busa

doi:10.1038/nbt0906-1065a

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The dog as a cancer model pp1065 - 1066

Chand Khanna, Kerstin Lindblad-Toh, David Vail, Cheryl London, Philip Bergman, Lisa Barber, Matthew Breen, Barbara Kitchell, Elizabeth McNeil, Jaime F Modiano, Steven Niemi, Kenine E Comstock, Elaine Ostrander, Susan Westmoreland & Stephen Withrow

doi:10.1038/nbt0906-1065b

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GM sterile mosquitoes[mdash]a cautionary note pp1067 - 1068

Bart G J Knols, Rebecca C Hood-Nowotny, Herve Bossin, Gerald Franz, Alan Robinson, Wolfgang R Mukabana & Samuel K Kemboi

doi:10.1038/nbt0906-1067

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Reply to GM sterile mosquitoes[mdash]a cautionary note p1068

doi:10.1038/nbt0906-1068a

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Sequencing errors or SNPs at splice-acceptor guanines in dbSNP? pp1068 - 1070

Matthias Platzer, Michael Hiller, Karol Szafranski, Niels Jahn, Jochen Hampe, Stefan Schreiber, Rolf Backofen & Klaus Huse

doi:10.1038/nbt0906-1068b

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Data integration gets 'Sloppy' pp1070 - 1071

Jonas S Almeida, Chuming Chen, Robert Gorlitsky, Romesh Stanislaus, Marta Aires-de-Sousa, Pedro Eleuterio, Joao Carrico, Antonio Maretzek, Andreas Bohn, Allen Chang, Fan Zhang, Rahul Mitra, Gordon B Mills, Xiaoshu Wang & Helena F Deus

doi:10.1038/nbt0906-1070

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Replacing cRNA targets with cDNA reduces microarray cross-hybridization pp1071 - 1073

Aron C Eklund, Leah R Turner, Pengchin Chen, Roderick V Jensen, Gianfranco deFeo, Anne R Kopf-Sill & Zoltan Szallasi

doi:10.1038/nbt0906-1071

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Commentary

Why spurning food biotech has become a liability pp1075 - 1077

Henry I Miller, Gregory Conko & Drew L Kershen

doi:10.1038/nbt0906-1075

Abstract | Full Text | PDF

The breeder's dilemma[mdash]yield or nutrition? pp1078 - 1080

Cindy E Morris & David C Sands

doi:10.1038/nbt0906-1078

Abstract | Full Text | PDF

Investor's Lab

The protection racket p1081

Tom Jacobs

doi:10.1038/nbt0906-1081

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Features

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Oversight of US genetic testing laboratories pp1083 - 1090

Kathy L Hudson, Juli A Murphy, David J Kaufman, Gail H Javitt, Sara H Katsanis & Joan Scott

doi:10.1038/nbt0906-1083

Abstract | Full Text | PDF

Patents

Evidence and anecdotes: an analysis of human gene patenting controversies pp1091 - 1094

Timothy Caulfield, Robert M Cook-Deegan, F Scott Kieff & John P Walsh

doi:10.1038/nbt0906-1091

Abstract | Full Text | PDF

Recent patent applications in tissue engineering p1095

doi:10.1038/nbt0906-1095

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News and Views

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Artificial sperm and epigenetic reprogramming pp1097 - 1098

Diana Lucifero & Wolf Reik

doi:10.1038/nbt0906-1097

Abstract | Full Text | PDF

The worm turns for antimicrobial discovery pp1098 - 1100

Amit P Bhavsar & Eric D Brown

doi:10.1038/nbt0906-1098

Abstract | Full Text | PDF

The sweet side of biomarker discovery pp1100 - 1101

Carlos J Bosques, S Raguram & Ram Sasisekharan

doi:10.1038/nbt0906-1100

Abstract | Full Text | PDF

Research Highlights p1102

doi:10.1038/nbt0906-1102

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Foreword

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Empowering microarrays in the regulatory setting p1103

Daniel A. Casciano & Janet Woodcock

doi:10.1038/nbt0906-1103

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Opinion and Comment

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Commentary

Impact of microarray data quality on genomic data submissions to the FDA pp1105 - 1107

Felix W Frueh

doi:10.1038/nbt0906-1105

Abstract | Full Text | PDF

A framework for the use of genomics data at the EPA pp1108 - 1111

David J Dix, Kathryn Gallagher, William H Benson, Brenda L Groskinsky, J Thomas McClintock, Kerry L Dearfield & William H Farland

doi:10.1038/nbt0906-1108

Abstract | Full Text | PDF

Data quality in genomics and microarrays pp1112 - 1113

Hanlee Ji & Ronald W Davis

doi:10.1038/nbt0906-1112

Abstract | Full Text | PDF

Research

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Analysis

Evaluation of DNA microarray results with quantitative gene expression platforms pp1115 - 1122

Roger D Canales, Yuling Luo, James C Willey, Bradley Austermiller, Catalin C Barbacioru, Cecilie Boysen, Kathryn Hunkapiller, Roderick V Jensen, Charles R Knight, Kathleen Y Lee, Yunqing Ma, Botoul Maqsodi, Adam Papallo, Elizabeth Herness Peters, Karen Poulter, Patricia L Ruppel, Raymond R Samaha, Leming Shi, Wen Yang, Lu Zhang & Federico M Goodsaid

doi:10.1038/nbt1236

Abstract | Full Text | PDF

Using RNA sample titrations to assess microarray platform performance and normalization techniques pp1123 - 1131

Richard Shippy, Stephanie Fulmer-Smentek, Roderick V Jensen, Wendell D Jones, Paul K Wolber, Charles D Johnson, P Scott Pine, Cecilie Boysen, Xu Guo, Eugene Chudin, Yongming Andrew Sun, James C Willey, Jean Thierry-Mieg, Danielle Thierry-Mieg, Robert A Setterquist, Mike Wilson, Anne Bergstrom Lucas, Natalia Novoradovskaya, Adam Papallo, Yaron Turpaz, Shawn C Baker, Janet A Warrington, Leming Shi & Damir Herman

doi:10.1038/nbt1241

Abstract | Full Text | PDF

Evaluation of external RNA controls for the assessment of microarray performance pp1132 - 1139

Weida Tong, Anne Bergstrom Lucas, Richard Shippy, Xiaohui Fan, Hong Fang, Huixiao Hong, Michael S Orr, Tzu-Ming Chu, Xu Guo, Patrick J Collins, Yongming Andrew Sun, Sue-Jane Wang, Wenjun Bao, Russell D Wolfinger, Svetlana Shchegrova, Lei Guo, Janet A Warrington & Leming Shi

doi:10.1038/nbt1237

Abstract | Full Text | PDF

Performance comparison of one-color and two-color platforms within the Microarray Quality Control (MAQC) project pp1140 - 1150

Tucker A Patterson, Edward K Lobenhofer, Stephanie B Fulmer-Smentek, Patrick J Collins, Tzu-Ming Chu, Wenjun Bao, Hong Fang, Ernest S Kawasaki, Janet Hager, Irina R Tikhonova, Stephen J Walker, Liang Zhang, Patrick Hurban, Francoise de Longueville, James C Fuscoe, Weida Tong, Leming Shi & Russell D Wolfinger

doi:10.1038/nbt1242

Abstract | Full Text | PDF

Articles

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements pp1151 - 1161

MAQC Consortium

doi:10.1038/nbt1239

Abstract | Full Text | PDF

Rat toxicogenomic study reveals analytical consistency across microarray platforms pp1162 - 1169

Lei Guo, Edward K Lobenhofer, Charles Wang, Richard Shippy, Stephen C Harris, Lu Zhang, Nan Mei, Tao Chen, Damir Herman, Federico M Goodsaid, Patrick Hurban, Kenneth L Phillips, Jun Xu, Xutao Deng, Yongming Andrew Sun, Weida Tong, Yvonne P Dragan & Leming Shi

doi:10.1038/nbt1238

Abstract | Full Text | PDF

Errata

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Erratum: Alfimeprase to succeed Genentech's alteplase? p1170

Brian Vastag

doi:10.1038/nbt0906-1170a

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Erratum: Diversifying chemical arrays p1170

Laura DeFrancesco

doi:10.1038/nbt0906-1170b

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Corrigenda

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Corrigendum: All in the RNA family p1170

Beverly L. Davidson

doi:10.1038/nbt0906-1170c

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Corrigendum: Engineering and characterization of a superfolder green fluorescent protein p1170

Jean-Denis Pe[acute]delacq, Stephanie Cabantous, Timothy Tran, Thomas C Terwilliger & Geoffrey S Waldo

doi:10.1038/nbt0906-1170d

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Retraction

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Retraction: Identification of genes that function in the TNF-[alpha]-mediated apoptotic pathway using randomized hybrid ribozyme libraries p1170

Hiroaki Kawasaki, Reiko Onuki, Eigo Suyama & Kazunari Taira

doi:10.1038/nbt0906-1170e

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Naturejobs

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Careers and Recruitment

Five attributes of a successful manager in a research organization pp1171 - 1174

Grace H W Wong

doi:10.1038/nbt0906-1171

Abstract | Full Text | PDF

People

People p1176

doi:10.1038/nbt0906-1176

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| | Director | | Biotechnology | | Macquarie University | | Sydney, Australia |
| | |
| Associate Director | | Biotechnology|Cancer Research / Oncology|Drug Discovery|Molecular Biology | | Genentech | | South San Francisco, CA United States
| | |
| Scientist-Immunology Diagnostics | | Bioinformatics|Biotechnology|Drug Discovery|Immunology | | Genentech | | South San Francisco, CA United States
| | |
| Senior Program Specialist / Program Officer | | Biotechnology|Genetics|Genomics|Molecular Biology|Policy & Social Sciences| | | International Development Research Centre / Centre de Recherches pour le Developpement International | | Ottawa, ON Canada
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| Editorial Intern Position | | Biotechnology|Genetics|Immunology|Molecular Biology|Neuroscience| | | Nature Publishing Group | | New York, NY United States
| | |
| Researcher | | Biomedical Sciences|Biotechnology|Public Health|Medical Sciences|Clinical Medicine| | | Institut National De La Sant Et De La Recherche Medicale | | Paris Cedex, France
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