Subject: Drug [email-masked] 18 August 2006

From: "Drug Discovery"<[email-masked]>
Date: Fri, 18 Aug 2006 07:00:56 -0400 (EDT)

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18 August 2006 Issue

Horizon Symposia

News

Research highlights

Research & reviews

Market analysis

Naturejobs drug discovery

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| News |

Cancer: Off by a whisker
Much of what we know about cancer comes from studying mice, and potential therapies are tested in the animals. But the differences between the species can scupper the best laid plans of researchers and drug companies.

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AIDS meeting urged to rethink prevention strategy
Researchers seek new ways to fight disease.

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More fizz at Pfizer?
Young blood is taking the helm at the world's biggest drug firm. Colin Macilwain assesses whether this is likely to revive its share price.

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Verdict confirms fate of 'elephant man' drug volunteers
Researchers verify 'cytokine storm' theory of troubled trial.

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more news

| Research highlights |

RNA interference: Targeted delivery by an RNA double
Two methods could overcome the delivery problems of siRNAs

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Asthma and allergy: TSLP aids memory
Cells identified that could help maintain and reactivate memory cells in allergic disease.

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Oncogenomics: Cross-species comparisons
Genomics identifies oncogenes in liver cancer.

more research highlights

| Market analysis |

From the analyst's couch: Anaemia therapies
Successful commercialization of new drugs by a small company will probably require partnering with larger players.

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Fresh from the pipeline: Quadrivalent human papillomavirus recombinant vaccine
First vaccine for the prevention of cervical cancer approved.

more market analysis articles

| Research & reviews |

Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
The truth on how sildenafil evolved from a potential angina treatment to a blockbuster drug for erectile dysfunction and beyond.

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Global mapping of pharmacological space
Integrating several sources of medicinal chemistry data provides a framework for increasing research productivity.

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Drug penetration in solid tumours
How to overcome one of the biggest barriers in cancer treatment.

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Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
Potential problems for cancer wonder drug.

more research & reviews

| Naturejobs drug discovery |

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Simon Campbell
The ex-research head of Pfizer discusses why bigger isn’t necessarily better for R&D productivity.

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